| Sacramento Kings | National Basketball Association | Sacramento | 1945 | ARCO Arena I, Power Balance Pavilion, Golden 1 Center, Municipal Auditorium, Kemper Arena, Omaha Civic Auditorium, Cincinnati Gardens, Edgerton Park Arena, Blue Cross Arena |
| Saetas de Oro | Copa Perú | — | — | — |
| Saint Louis Blues | — | — | 1967 | Enterprise Center |
| Saint Louis Cardinals | Grandes Ligas de Béisbol | — | 1882 | Busch Stadium |
| Salerno Basket 92 | — | — | — | — |
| San Antonio Spurs | National Basketball Association | — | 1967 | Alamodome, Kay Bailey Hutchison Convention Center, HemisFair Arena, Fort Worth Convention Center, Frost Bank Center, Moody Coliseum, CityBank Coliseum |
| San Diego FC | Major League Soccer | San Diego | 18 de mayo de 2023 | Snapdragon Stadium |
| San Francisco Gigantes | Grandes Ligas de Béisbol | San Francisco | 1883 | Oracle Park |
| San Jose Earthquakes | Major League Soccer | San José | 1995 | PayPal Park, Stevens Stadium |
| San Jose Sharks | — | — | 1991 | Cow Palace, SAP Center |
| Santa Marinella Basket | — | — | — | — |
| Santos Fútbol Club | Copa Perú | — | — | Estadio José Picasso Peratta |
| Scafati Basket | Lega Basket Serie A | Scafati | 1969 | PalaMangano |
| Seattle Kraken | — | — | 2021 | Climate Pledge Arena |
| Seattle Mariners | Grandes Ligas de Béisbol | — | 1977 | Kingdome, T-Mobile Park |
| Seattle Metropolitans | Pacific Coast Hockey League | Seattle | 1915 | — |
| Seattle Seahawks | National Football League | — | 1976 | Kingdome, Estadio Husky, Lumen Field |
| Seattle Sounders FC | Major League Soccer | Seattle | 2009 | Lumen Field |
| Seattle SuperSonics | — | Washington | 1967 | Kingdome, Climate Pledge Arena, Tacoma Dome |
| Sebastiani Basket Club Rieti | — | — | — | — |
| Senati FBC | Copa Perú | — | — | Estadio Mariano Melgar |
| Sheboygan Redskins | National Basketball Association | Sheboygan | 1938 | Playdium, Sheboygan Municipal Auditorium and Armory |
| Silver Basket Porto Torres | — | Porto Torres | — | — |
| Sisv Viterbo | — | Viterbo | — | — |
| Società Cestistica Mazzini | — | Bolonia | — | — |
| Società Ginnastica Roma | — | — | — | — |
| Società Ginnastica Triestina | — | Trieste | 1930 | — |
| Sport Boys Association | Torneo Descentralizado | — | 1927 | Estadio Miguel Grau |
| Sport Chorrillos | Copa Perú | — | — | Estadio Campeones del 36 |
| Sport Club Alcamo | — | Alcamo | — | — |
| Sport Huamanga | Copa Perú | — | 2002 | Estadio Ciudad de Cumaná |
| Sport José Gálvez | — | — | 1902 | Antiguo Estadio Nacional del Perú |
| Sport Juan Bielovucic | — | — | — | Antiguo Estadio Nacional del Perú |
| Sport Saenz Peña | — | — | 1906 | Estadio Telmo Carbajo |
| Sport Vallejo | Copa Perú | — | octubre 2002 | Estadio Mansiche |
| Sporting Bellavista | — | — | 1912 | Antiguo Estadio Nacional del Perú |
| Sporting Club Gira | — | Bolonia, Ozzano dell'Emilia | 1945 | — |
| Sporting Kansas City | Major League Soccer | Kansas City | 1995 | Sporting Park, CommunityAmerica Ballpark, Arrowhead Stadium |
| Sportivo Melgar | — | — | 14 de julio de 1925 | Antiguo Estadio Nacional del Perú |
| Sportivo Tarapacá Ferrocarril | — | — | 15 de octubre de 1911 | Estadio Nacional del Perú |
| St. Louis City SC | Major League Soccer | San Luis | 20 de agosto de 2019 | Energizer Park |
| St. Louis Hawks | National Basketball Association | — | — | — |
| Starlight Valmadrera | — | — | — | — |
| Stella Azzurra Roma | — | Roma | 1938 | — |
| Sutor Basket Montegranaro | — | Montegranaro | 1947 | Banca Marche Palace |